Hamilton and the rest of Mercedes-AMG made their mark as early as qualifying.
Valtteri Bottas was second, securing Mercedes' first one-two of the season.
"It has been a rejuvenating experience", he said.
"It is the greatest feeling to come here and have that kind of performance and then win convincingly", he said. But once the Safety Car pulled in at the end of lap six, Hamilton was in a race nearly on his own, a rapid first stint suggested that there was one man in contention for the win. "I think Red Bull will really be strong and Ferrari was on the pole previous year. That is encouraging for me because I have been racing a long time - to still have that feeling when you win and that happiness". "So we need to stay calm and humble, because it can be a different ball game again next time". Hamilton was serene but stressed victory had by no means been a simple task. "I think it will be an interesting race".
"I never believed we can do a one-stop", he said.
Despite the upturn, concerns remain at Mercedes as to whether their auto is able to put its tyres in the correct temperature operating window.
"I think the last couple of races we were a bit closer in terms of pace, we had a vehicle fighting for the win, having winning pace".
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Wolff, however, said: "Why our vehicle doesn't like to be quick around the corners in Monaco, we haven't found out yet - but we know what went wrong previous year. We just need to continue like that, and for me also the wins will come".
"Why our auto doesn't like to be quick around the corners in Monaco we haven't found yet".
"Already this is the hardest year that I've faced, in the auto, at the track, away from the track", he told Sky F1.
"Of course they knew it would do because they said it was going to work but when they go away and do their expertise and come back on certain area on the vehicle you'll start to see the benefits from it". The team's grid position helped them get a quick getaway from the start, pulling ahead of the Red Bulls and the Ferraris right from the launch.
"It was going to be tough being behind Sebastian all the time". He said: "If you're happy with your wife, you don't look at other women". Daniel Ricciardo, who also had a relatively quiet race, rounded up the top five. "They are going to be rapid in Monaco". That is all downforce.